Moreover, black seed (2 g/day) owed clinically valuable anti-H. pylori effect comparable to triple therapy [109] and this can provide a scientific basis for the exploration of potential uses of this valued seed for the treatment of H. pylori-induced gastric ulcers. Chronic toxicity was also studied in rats treated daily with an oral dose of 2 ml/kg for 12 weeks’ black cumin oil, while alterations in vital liver enzyme levels and histopathological modifications (heart, liver, kidneys, and pancreas) were not detected [151]. Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment.

[55] and Qidwai et al. In addition to these drugs, rationale and evidence have been presented to use chloroquine to treat COVID-19, arguably with certain precautions and criticism. A. Blumenfeld-Olivares, E. Garicano-Vilar, M. Á. Cuadrado, M. J. Ciudad-Cabañas, and L. Collado-Yurrita, “Differences in the effect of plant sterols on lipid metabolism in men and women,”, S. Cheikh-Rouhou, S. Besbes, B. Hentati, C. Blecker, C. Deroanne, and H. Attia, “, M. Zaunschirm, M. Pignitter, J. Kienesberger et al., “Contribution of the ratio of tocopherol homologs to the oxidative stability of commercial vegetable oils,”, B. K. Mehta, P. Mehta, and M. Gupta, “A new naturally acetylated triterpene saponin from Nigella sativa,”, B. K. Mehta, V. Pandit, and M. Gupta, “New principles from seeds of Nigella sativa,”, T. Morikawa, F. Xu, Y. Kashima, H. Matsuda, K. Ninomiya, and M. Yoshikawa, “Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa,”, T. Morikawa, F. Xu, K. Ninomiya, H. Matsuda, and M. Yoshikawa, “Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin,”, M. S. Atta-ur-Rahman, H. Cun-Heng, and J. Clardy, “Isolation and structure determination of Nigellicine, a novel alkaloid from the seeds of, M. S. Atta-ur-Rahman, S. S. Hasan, M. I. Choudhary, C.-Z.

Percentage (%) Suppression of parasitaemia in mice treated with Nigella sativa seed in feed (NSSF) only, NSSF+ CQ (Chloroquine) and CQ only. Materials and methods: Chloroquine sensitive P. berghei, NK65 strain was used for the study. The Prophet Mohammed (PBUH) had described the curative powers of the black seed as “Hold on to use this black seed, as it has a remedy for every illness except death” [33]. Stress is the chief triggering aspect in the initiation of depression and this premise is steadily supported by various clinical observations.

The effect of N. sativa seed on the glycemic control of patients with type-2 diabetes (DM-2) was also used as an adjunctive treatment added to their oral hypoglycemic agents. Get the latest research from NIH: https://www.nih.gov/coronavirus. Ni, and J. Clardy, “Nigellidine - A new indazole alkaloid from the seeds of Nigella sativa,”, Z. Ali, D. Ferreira, P. Carvalho, M. A. Avery, and I. A. Badary, O. Kabore A. Harare: African Health Monitor (WHO); 2000. By continuing you agree to the use of cookies. and infectious disease (bacterial, fungal, viral, and parasitic infections).

The aim of the study was to investigate the effects of dietary combination of Nigella sativa seed and oil extracts with chloroquine (CQ), and how these combinations enhance CQ efficacy in mice infected with Plasmodium berghei and their survival rates. Comparison of Percentage (%) parasitaemia in mice treated with various concentrations of Nigella sativa oil extract (5 mg/kg and 10 mg/kg), 10 mg/kg + CQ (Chloroquine), CQ (Chloroquine) alone, UNTIC (untreated infected control) and 3% DMSO. (i) NSO revealed a significant antiproliferative activity in both initiation and post-initiation phases, Mouse model of colorectal carcinogenesis & C26 cell, TQ (5 mg/kg) for 3 weeks & TQ (0, 20, 40, 60, (i) Reduction in malignant and benign colon tumor sizes, tumors in the lungs and in diverse parts of the alimentary canal principally the oesophagus and fore stomach, NSO (1ml/kg) and TQ (10 mg/kg) EOD for 12 days. The structure, function, motility, and survival of sperm are deleteriously affected by oxidative stress that prominently leads to infertility.

Maryam, A.-A. Further there is no drug that is specific to treat COVID-19. A number of herbal products such as the seed of N. sativa have been used and claimed to have positive effects against elevated blood pressure (BP). Ebrahim M. Yimer, Kald Beshir Tuem, Aman Karim, Najeeb Ur-Rehman, Farooq Anwar, "Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses", Evidence-Based Complementary and Alternative Medicine, vol. The N. sativa treatment targeted the cell wall, plasma membrane, and membranous organelles, mainly in the nuclei and mitochondria as were evident in the morphology of these toxigenic fungi [110]. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. PLoS Med. Li, Y. Liao, and H.-G. Yu, “Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer,”, Ç. Şakalar, K. İzgi, B. İskender et al., “The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer,”, R. Khalife, M. H. Hodroj, R. Fakhoury, and S. Rizk, “Thymoquinone from nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro,”, S. Gurunath, Z. Pandian, R. A. Anderson, and S. Bhattacharya, “Defining infertility-a systematic review of prevalence studies,”, R. J. Aitken, T. B. Smith, M. S. Jobling, M. A. Baker, and G. N. De Iuliis, “Oxidative stress and male reproductive health,”, C. Wright, S. Milne, and H. Leeson, “Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility,”, F. M. Awah, P. N. Uzoegwu, P. Ifeonu et al., “Free radical scavenging activity, phenolic contents and cytotoxicity of selected Nigerian medicinal plants,”, S. S. Ashraf, M. V. Rao, F. S. Kaneez et al., “Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress,”, R. Parandin, N. Yousofvand, and R. Ghorbani, “The enhancing effects of alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and testosterone in male rats,”, M. Kolahdooz, S. Nasri, S. Z. Modarres, S. Kianbakht, and H. F. Huseini, “Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial,”, O. Phytosterols are also important as characteristic compounds for assessing the quality of vegetable oils and food labeling. Conclusions: The intragastric supplementation of TQ (20 mg/mL) in aluminum trichloride and D-galactose induced neurotoxicity in rats showed a meaningful improvement of cognition, SOD, and total antioxidant capacity while reducing acetylcholinesterase activities. Survival rate in NSSF and NSOF and in combination with CQ groups was 100 and 60.0% for CQ alone.

Further benefits to use N. sativa could be augmented by Zn supplement. The major sterols identified were β-sitosterol, campesterol, stigmasterol, and 5-avenasterol [19, 22]. Evidence proves that some herbal medicines can reduce negative effects of oxidative stress by salvaging free radicals [145].

A. Adaramoye, C. M. Nneji, C. O. Falade, E. O. Farombi, and O. G. Ademowo, “Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis,”, R. Schneider-Stock, I. H. Fakhoury, A. M. Zaki, C. O. El-Baba, and H. U. Gali-Muhtasib, “Thymoquinone: fifty years of success in the battle against cancer models,”, E.-S. A. Arafa, Q. Zhu, Z. I. Shah et al., “Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells,”, V. S. Periasamy, J. Athinarayanan, and A. Similarly, the oil of N. sativa and thymoquinone administration markedly ameliorated cisplatin-induced alteration on carbohydrate biotransformation and enzymatic and nonenzymatic antioxidant defense system in the gastric mucosa [43]. Thymoquinone also revealed a significant bactericidal activity against gram-positive cocci with MICs ranging from 8 to 32 μg/mL and proved the minimum biofilm inhibition concentration at 22 and 60 μg/mL for S. aureus and S. epidermidis, respectively [108]. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The COVID-19 has been declared a pandemic while there is no specific medicine against its causative agent SARS-CoV-2. For instance, previous clinical studies conducted by Dehkordi et al. Interestingly, patients (30) with hepatitis C virus (HCV) infection, who were not eligible for IFN-α/ribavirin therapy showed significant improvement in HCV viral load (16.67% became seronegative and 50% showing significant decrement) and proved laboratory parameter like total protein, red blood cell, and platelet count, decreased fasting blood glucose, and postprandial glucose in both diabetic and nondiabetic HCV patients and reduced lower-limb edema after they are managed with black cumin seed oil [116].

The latest speculation circulating on the internet is that kalonji seeds (Nigella Sativa) can cure Covid-19. Materials and methods: Given those benefits, this review paper describes how N. sativa in combination with Zn could be useful as a complement to COVID-19 treatment.

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