Effect of prolonged desmethylimipramine administration on the pulmonary clearance of 5-hydroxytryptamine and beta-phenylethylamine in rats. Crit Rev Food Sci Nutr. Phenethylamine is taken by mouth for improving athletic performance, depression, weight loss, and to improve mood and attention. 2C-T-7, 2C-T-2) of phenethylamines. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [5] Benzodifurans, such as ‘FLY’ (tetrahydrobenzodifuranyl) and ‘Dragonfly’ (benzodifuranyl aminoalkanes) are potent hallucinogens. Do not take phenethylamine if you are taking pentazocine (Talwin). Ingestion is the most common route of administration of phenethylamines. 1987;92(2):243-55. Phenethylamines These are strong stimulants and hallucinogens. Just imagine a young person suffering from symptoms like these when all he wanted was to go to a party and have a good time: With some of these drugs, a person may go suffer an intense rigidity of muscles. Phenethylamine is POSSIBLY UNSAFE for most people when taken by mouth appropriately. It’s classifiedas a natural monoamine alkaloid and trace amine. Tyramine and phenylethylamine biosynthesis by food bacteria. 2002;34(3):243-8. This might cause too much serotonin in the brain and could result in serious side effects including heart problems, shivering, and anxiety. 2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system?
It is also a central nervous system depressant which may mean that it causes a person to stop breathing or slows the heart to a dangerous or even fatal rate. PMMA, in combination with PMA (a substance listed in Schedule I of the 1971 United Nations Convention on Psychotropic Substances), has been frequently found in tablets that carry a similar logo to ‘ecstasy’.[7].

Dextromethorphan (Robitussin DM, others) can also affect serotonin. 4-bromo-2,5-dimethoxyphenethylamine (2C-B), synthesized by Shulgin in 1974. Marcobal A, De las Rivas B, Landete J, et al. Psychopharmacology (Berl). Bipolar disorder: Use of phenethylamine might cause people with bipolar disorder to convert from depression to mania. One drug from this class has been widely used in Europe and the US for several years - Ecstasy, also known as … Disclaimer: Individual results are not guaranteed and may vary. Beck O, Helander A, Karlson-Stiber C, et al. In the 1980s and 1990s, Alexander Shulgin, a biochemist and pharmacologist, reported the synthesis of numerous new psychoactive compounds. Some medications for depression also increase serotonin. pdf; accessed in: September 2012); Wood, D.M., Looker, J.J., Shaikh, [10]Andreasen, M.F., Telving, R., Birkler, R., Schumacher, B. and Johannsen, M., ‘A fatal poisoning involving Bromo-Dragonfly’, Annales de Toxicologie Analitique, 20 (1), 1-55; Personne, M., Hulten, P., ‘Bromo-Dragonfly, a life threatening designer drug’, Journal: Clinical Toxicology, 2008, 46, 379-80, [11]Miyajima, M., Matsumoto, T and Ito, S., ‘2C-T-4 intoxication: acute psychosis caused by a designer drug’, Journal: Psychiatry and Clinical Neurosciences, 2008, 62, 243, [12]Curtis, B., Kemp, P., Harty, L., Choi, C. and Christensen, D., ‘Postmortem identification and quantitation of 2,5-dimethoxy-4-n-propylthiophenethylamine using GC-MSD and GC-NPD’, Journal of Analytical Toxicology, 2003, 27, 493-98, [13]Ling, L.H., Marchant, C., Buckley, N. A., Prior, M., Irvine, R.J., ‘Poisoning with the recreational drug paramethoxyamphetamine (‘ death ’)’, Medical Journal of Australia, 2001, 174, 453-55; De Letter, E.A., Coopman, V.A., Cordonnier, J.A. The team found the potency of synthetic analogues of mescaline such as 2C-B and DOB, to exceed that of many naturally occurring hallucinogens. Simple variations on the mescaline molecule (a natural phenylethylamine) led to the synthesis of powerful hallucinogenic substances, e.g. Seizures of phenethylamines were first reported from the United States and European countries and since 2009 substances such as 2C-E, 2C-I, 4-FA and PMMA have been commonly reported by several countries in different regions. DOC, DOI) and the ‘2C series’ (e.g. Phenethylamines included in the ‘D series’ are described to be longer lasting, more potent and reportedly more liable to induce vasoconstriction than other members of the phenethylamine family. Special Precautions & Warnings: Kusaga A. Phenethylamine increases a chemical in the brain called serotonin. View abstract. 1991;29(1):15-22. This might cause serious side effects including heart problems, shivering, and anxiety.

2C-T-7: Vomiting, headaches, confusion, delirium, high blood pressure. Also, it might cause rapid heart rate, anxiety, or agitation. When Ecstasy is used in a party or dance club environment, it is known for causing people who are dancing for hours to get dehydrated and overheated. Do not take phenethylamine if you are taking meperidine (Demerol).

2002;52(3):372-4. Phenylethylamine — also sometimes called PEA, phenethylamine HCL or beta phenylethylamine — is an organic compound that’s found in the human body and also taken by mouth for several purposes. Miley (MDA or 3,4-methylenedioyamphetamine), 2C-B: Heart disturbances, confusion, dehydration (which can lead to overheating and organ failure), 2C-I: Seizures, confusion, kidney failure, skyrocketing blood pressure. Baker G, Bornstein R, Rouget A, et al. View abstract. Clinical observations. 2011;116(2):164-76. 2012;52(5):448-67. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Sabelli HC, Javaid JI. Drug Metab Dispos.

Altern Med Rev 1998;3:271-80. Do not take phenethylamine if you are taking desipramine (Norpramin). [1]The phenethylamines also include ring substituted substances such as the ‘2C series’, ring substituted amphetamines such as the ‘D series’ (e.g.DOI, DOC), benzodifurans (e.g. View abstract. 2001;159(1):21-30. Phenethylamine increases a chemical in the brain. View abstract. Increased urine phenylethylamine after methylphenidate treatment in children with ADHD. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Stimulants mediate the actions of dopamine, norepinephrine and/or serotonin, mimicking the effects of traditional drugs such as cocaine, amphetamine, methamphetamine, and ecstasy. Shannon H, Cone E, Yousefnejad D. Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. Some people have also suffered a stoppage of blood flow to the extremities which caused them to lose fingertips or toes.
1997;17(2):206-10. Keep in mind that natural products are not always necessarily safe and dosages can be important. Paterson I, Juorio A, Boulton A. Smith T. Phenethylamine and related compounds in plants. It can also be made in the laboratory. [4] Several substances were synthesized, including a wide range of benzodifuranyl substances, later known as the ‘FLY’. View abstract. 1982;223(1):190-6. J Neurochem. Singhal AB, Caviness VS, Begleiter AF, et al. The ‘2C’ series differs from the ‘D’ series only by a slight modification in the chemical structure, and their psychoactive effects have been reported to be dose dependant, ranging from mere stimulant effect at lower doses, with hallucinogenic and entactogenic effects at higher doses.[3].

1990;55(6):1827-37.

Bailey B, Philips S, Boulton A. J Pharmacol Exp Ther. Some medications used for depression also increase serotonin. View abstract. Insufficient Evidence to Rate Effectiveness for... Vitamin D Deficiency: How Much Vitamin D Is Enough? [2]This included the ‘D series’ (e.g. View abstract. Most phenethylamines act as either central nervous system stimulants, or as hallucinogens. Phenethylamines refer to a class of substances with documented psychoactive and stimulant effects and include amphetamine, methamphetamine and MDMA, all of which are controlled under the 1971 Convention. Baker GB, Coutts RT, Rao TS. J Pharmacol Exp Ther. 1977;127(2):317-322. Phenylethylaminergic mechanisms in attention-deficit disorder. [9]King’s College London. J Anal Toxicol. Supplements are likely unsafe for most people and there is insufficient evidence that they improve mood, weight loss, or cognitive function. 1996;8(2):168-71. Taking phenethylamine along with these medications used for depression might cause too much serotonin in the body, and serious side effects including heart problems, shivering, and anxiety. Minchin RF, Barber HE, Ilett KF. Eur J Pharmacol. 1987;12(2):173-8. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Do not take phenethylamine if you are taking dextromethorphan (Robitussin DM, and others). J Neurochem.

Journal of Pharmacy and Pharmacology. 2005;26(5):274-81. Phenethylamine can affect a brain chemical called serotonin. Phenethylamine is a trace amine found in tiny amounts in the brain that increases the release of the “happy hormones” dopamine and serotonin. 1977;16(1):9-18. The muscles of the body may simply freeze up and be unable to let go.

The chain reaction sometimes cannot be stopped. View abstract. View abstract. Phenethylamine works similar to the drug amphetamine, and may cause similar side effects. Neuropharmacological and neurochemical properties of N-(2-cyanoethyl)-2-phenylethylamine, a prodrug of 2-phenylethylamine.

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